Does Quinapril Hydrochloridehydrochlorothiazide Interact with Lithium?
CDI records a major classification for Quinapril Hydrochloridehydrochlorothiazide and Lithium. The stored summary is: Increased serum lithium levels and symptoms of lithium toxicity reported with ACE inhibitors; thiazides further reduce lithium renal clearance, increasing toxicity risk. The mechanism involves reduced renal clearance of lithium by both ace inhibitor and thiazide diuretic. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Quinapril Hydrochloridehydrochlorothiazide Class
- Thiazide Diuretic
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Reduced renal clearance of lithium by both ACE inhibitor and thiazide diuretic
What To Tell Your Doctor or Pharmacist
If you are taking Quinapril Hydrochloridehydrochlorothiazide and your doctor is considering prescribing Lithium (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider