Quinidine + Acetaminophen And Codeine Phosphate Interaction
Majorinteraction on record
Description
CYP2D6 inhibitor that increases codeine plasma concentration but decreases morphine concentration, potentially causing reduced analgesic efficacy or opioid withdrawal symptoms. Discontinuation may cause increased morphine levels and potentially fatal respiratory depression.
Mechanism
CYP2D6 inhibition reduces codeine metabolism to active metabolite morphine
Source: NLP:acetaminophen and codeine phosphate