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Does Acetaminophen And Codeine Phosphate Interact with Fluoxetine?

Acetaminophen And Codeine Phosphate and Fluoxetine have a major drug interaction according to U.S. FDA drug labeling data. CYP2D6 inhibitor that increases codeine plasma concentration but decreases morphine concentration, potentially causing reduced analgesic efficacy or opioid withdrawal symptoms. Discontinuation may cause increased morphine levels and potentially fatal respiratory depression. The mechanism involves cyp2d6 inhibition reduces codeine metabolism to active metabolite morphine. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Acetaminophen And Codeine Phosphate and Fluoxetine occurs because cyp2d6 inhibition reduces codeine metabolism to active metabolite morphine. Clinically, this means cyp2d6 inhibitor that increases codeine plasma concentration but decreases morphine concentration, potentially causing reduced analgesic efficacy or opioid withdrawal symptoms. discontinuation may cause increased morphine levels and potentially fatal respiratory depression. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Acetaminophen And Codeine Phosphate and your doctor is considering prescribing Fluoxetine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Acetaminophen And Codeine Phosphate(Acetaminophen And Codeine Phosphate)+💊 Fluoxetine(Fluoxetine)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
—
Source
NLP:acetaminophen and codeine phosphate

What this means in plain English

CYP2D6 inhibitor that increases codeine plasma concentration but decreases morphine concentration, potentially causing reduced analgesic efficacy or opioid withdrawal symptoms. Discontinuation may cause increased morphine levels and potentially fatal respiratory depression.

What the FDA label says

"CYP2D6 inhibition reduces codeine metabolism to active metabolite morphine"

📖 Source: NLP:acetaminophen and codeine phosphate

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.