Quinidine + Tramadol Hydrochloride And Acetaminophen Interaction

Majorinteraction on record

Description

CYP2D6 inhibitor that increases tramadol plasma concentration and decreases M1 concentration, risking seizures, serotonin syndrome, opioid withdrawal, and respiratory depression.

Mechanism

Inhibition of CYP2D6 metabolism of tramadol

Source: NLP:tramadol hydrochloride and acetaminophen