Does Tramadol Hydrochloride And Acetaminophen Interact with Mao Inhibitors?
CDI records a major classification for Tramadol Hydrochloride And Acetaminophen and Mao Inhibitors. The stored summary is: Increase tramadol plasma concentration, potentially causing seizures, serotonin syndrome, opioid toxicity, and potentially fatal respiratory depression. The mechanism involves inhibition of cyp3a4 metabolism of tramadol, increasing m1 formation via cyp2d6. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of CYP3A4 metabolism of tramadol, increasing M1 formation via CYP2D6
What To Tell Your Doctor or Pharmacist
If you are taking Tramadol Hydrochloride And Acetaminophen and your doctor is considering prescribing Mao Inhibitors (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider