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Does Rabeprazole Sodium Interact with Mycophenolate?

The ACIPHEX label discusses reduced exposure to mycophenolic acid when proton-pump inhibitors are used with mycophenolate mofetil. Reduced gastric acidity can affect absorption.

Label evidence and limitations

Named-drug label evidence. The source specifies MMF, whereas this page’s drug name is broader. The label states that the clinical relevance to organ rejection has not been established.

Product scope: ACIPHEX oral delayed-release rabeprazole tablets and mycophenolate mofetil (MMF).

Read the DailyMed label: These highlights do not include all the information needed to use ACIPHEX DELAYED-RELEASE TABLETS safely and effectively. See full prescribing information for ACIPHEX DELAYED-RELEASE TABLETS. ACIPHEX ® (rabeprazole sodium) delayed-release tablets, for oral use Initial U.S. Approval: 1999
Section: 7 Drug Interactions — Mycophenolate mofetil. Compared version 3, label date 2026-01-27. The linked label may be updated after this comparison.

This comparison uses the label identifier saved with the CDI record. The compared version may be newer than the original extraction.

AI-assisted source comparison dated 2026-10-16. This is a comparison of label text, not independent clinical review or an individual safety assessment. CDI's stored severity category is not an FDA-assigned rating. Confirm your exact medicines and formulations with your pharmacist or prescriber before changing treatment.

Stored CDI classification: Moderate
Management: Confirm exact products with your pharmacist
Data Source: Product label via NLM DailyMed

What To Tell Your Doctor or Pharmacist

If you are taking Rabeprazole Sodium and your doctor is considering prescribing Mycophenolate (or vice versa), make sure to:

Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
Ask whether the benefits of combining these medications outweigh the risks for your specific situation
Ask what symptoms to watch for that would indicate the interaction is causing problems
Never stop or change either medication without first consulting your healthcare provider

💊 Rabeprazole Sodium(Aciphex)+💊 Mycophenolate

Severity & Interaction Details

🟡

Stored CDI classification: moderate

Named-drug label evidence

The source specifies MMF, whereas this page’s drug name is broader. The label states that the clinical relevance to organ rejection has not been established.

Stored CDI scale

MinorContra

On record

Yes

Drug A class

—

Drug B class

—

Source

NLP:rabeprazole sodium

How to interpret this source comparison

The source specifies MMF, whereas this page’s drug name is broader. The label states that the clinical relevance to organ rejection has not been established.

About Rabeprazole Sodium and Mycophenolate

Rabeprazole Sodium is also sold under the brand name Aciphex.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: NLP:rabeprazole sodium

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.