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Does Rabeprazole Sodium Interact with Omeprazole?

Rabeprazole Sodium and Omeprazole have a unknown drug interaction according to U.S. FDA drug labeling data. This degree of inhibition is similar to that by omeprazole at equivalent concentrations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Unknown
Omeprazole Class
Proton Pump Inhibitor
Management
Consult your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Rabeprazole Sodium and your doctor is considering prescribing Omeprazole (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Rabeprazole Sodium(Aciphex)+💊 Omeprazole(Yosprala)

Severity & Interaction Details

ℹ️
unknown
Interaction documented — severity unclassified
The FDA label notes an interaction but the severity is not classified in our dataset.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Proton Pump Inhibitor
Source
FDA drug label - rabeprazole sodium

What this means in plain English

This degree of inhibition is similar to that by omeprazole at equivalent concentrations.

About Rabeprazole Sodium and Omeprazole

Omeprazole is a Proton Pump Inhibitor. You may recognize them by the brand names Aciphex and Yosprala. Both medications are taken by mouth.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.