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Does Radioactive Iodine Interact with Iohexol?

Radioactive Iodine and Iohexol have a major drug interaction according to U.S. FDA drug labeling data. IOHEXOL may interfere with thyroid uptake of radioactive iodine (I-131 and I-123), decreasing therapeutic and diagnostic efficacy. Avoid thyroid therapy or testing for up to 6 weeks post-IOHEXOL administration. The mechanism involves interference with thyroid iodine uptake. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Iohexol Class
Radiographic Contrast Agent
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Radioactive Iodine and Iohexol occurs because interference with thyroid iodine uptake. Clinically, this means iohexol may interfere with thyroid uptake of radioactive iodine (i-131 and i-123), decreasing therapeutic and diagnostic efficacy. avoid thyroid therapy or testing for up to 6 weeks post-iohexol administration. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Radioactive Iodine and your doctor is considering prescribing Iohexol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Radioactive Iodine+💊 Iohexol(Omnipaque)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Radiographic Contrast Agent
Source
NLP:iohexol

What this means in plain English

IOHEXOL may interfere with thyroid uptake of radioactive iodine (I-131 and I-123), decreasing therapeutic and diagnostic efficacy. Avoid thyroid therapy or testing for up to 6 weeks post-IOHEXOL administration.

What the FDA label says

"Interference with thyroid iodine uptake"

📖 Source: NLP:iohexol

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.