Does Radioactive Iodine Interact with Iopromide?
Radioactive Iodine and Iopromide have a moderate drug interaction according to U.S. FDA drug labeling data. IOPROMIDE may interfere with thyroid uptake of radioactive iodine (I-131 and I-123), decreasing therapeutic and diagnostic efficacy. Avoid thyroid therapy or testing for up to 6 weeks post-IOPROMIDE. The mechanism involves interference with thyroid iodine uptake. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Iopromide Class
- Radiographic Contrast Agent
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Radioactive Iodine and Iopromide occurs because interference with thyroid iodine uptake. Clinically, this means iopromide may interfere with thyroid uptake of radioactive iodine (i-131 and i-123), decreasing therapeutic and diagnostic efficacy. avoid thyroid therapy or testing for up to 6 weeks post-iopromide. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Radioactive Iodine and your doctor is considering prescribing Iopromide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider