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Does Radioactive Iodine Interact with Ioversol?

Radioactive Iodine and Ioversol have a major drug interaction according to U.S. FDA drug labeling data. Iodinated contrast agents interfere with thyroid uptake of radioactive iodine (I-131) and decrease therapeutic efficacy in thyroid carcinoma patients. Decreased efficacy lasts 6-8 weeks. The mechanism involves interference with thyroid uptake. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Ioversol Class
Radiographic Contrast Agent
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Radioactive Iodine and Ioversol occurs because interference with thyroid uptake. Clinically, this means iodinated contrast agents interfere with thyroid uptake of radioactive iodine (i-131) and decrease therapeutic efficacy in thyroid carcinoma patients. decreased efficacy lasts 6-8 weeks. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Radioactive Iodine and your doctor is considering prescribing Ioversol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Radioactive Iodine(Dairyland Brand Controlled Iodine Teat Dip)+💊 Ioversol(Optiray 320)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Radiographic Contrast Agent
Source
NLP:ioversol

What this means in plain English

Iodinated contrast agents interfere with thyroid uptake of radioactive iodine (I-131) and decrease therapeutic efficacy in thyroid carcinoma patients. Decreased efficacy lasts 6-8 weeks.

About Radioactive Iodine and Ioversol

Ioversol is a Radiographic Contrast Agent. Radioactive Iodine is also sold under the brand name Udderdine. Ioversol is given by intra-arterial infusion. Ioversol additionally carries an FDA boxed warning, the FDA's strongest safety alert.

What the FDA label says

"Interference with thyroid uptake"

📖 Source: NLP:ioversol

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.