Does Ranolazine Interact with Metformin Er 500 Mg?
CDI records a major classification for Ranolazine and Metformin Er 500 Mg. The stored summary is: OCT2/MATE inhibitor that reduces metformin clearance, increasing systemic exposure and risk of lactic acidosis. The mechanism involves interferes with renal tubular transport systems involved in metformin elimination. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Ranolazine Class
- Anti-anginal
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Interferes with renal tubular transport systems involved in metformin elimination
What To Tell Your Doctor or Pharmacist
If you are taking Ranolazine and your doctor is considering prescribing Metformin Er 500 Mg (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider