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Does Relugolix Interact with P Gp Inhibitors Oral?

Relugolix and P Gp Inhibitors Oral have a major drug interaction according to U.S. FDA drug labeling data. Co-administration increases relugolix exposure and risk of adverse reactions. If unavoidable, separate dosing by at least 6 hours and monitor frequently. The mechanism involves relugolix is a p-gp substrate; p-gp inhibition increases relugolix exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Relugolix Class
Gonadotropin Releasing Hormone Receptor Antagonist
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Relugolix and P Gp Inhibitors Oral occurs because relugolix is a p-gp substrate; p-gp inhibition increases relugolix exposure. Clinically, this means co-administration increases relugolix exposure and risk of adverse reactions. if unavoidable, separate dosing by at least 6 hours and monitor frequently. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Relugolix and your doctor is considering prescribing P Gp Inhibitors Oral (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Relugolix(Orgovyx)+💊 P Gp Inhibitors Oral

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
Gonadotropin Releasing Hormone Receptor Antagonist
Drug B class
—
Source
NLP:relugolix

What this means in plain English

Co-administration increases relugolix exposure and risk of adverse reactions. If unavoidable, separate dosing by at least 6 hours and monitor frequently.

What the FDA label says

"Relugolix is a P-gp substrate; P-gp inhibition increases relugolix exposure"

📖 Source: NLP:relugolix

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.