Does Rifabutin Interact with Nelfinavir?
Rifabutin and Nelfinavir have a unknown drug interaction according to U.S. FDA drug labeling data. Nelfinavir 1250 mg twice a day for 7-8 days 150 mg once a day for 8 days HIV infected patients (11) ↑ AUC by 83%, e ↑ C max by 19% Reduce rifabutin dose by 50% (to 150 mg once a day) and increase the nelfinavir dose to 1250 mg twice a day. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Rifabutin Class
- Rifamycin Antimycobacterial
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Rifabutin and your doctor is considering prescribing Nelfinavir (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider