Does Nelfinavir Interact with Esomeprazole?
CDI records a contraindicated classification for Nelfinavir and Esomeprazole. The stored summary is: Concomitant use is not recommended. Co-administration decreases nelfinavir serum levels (AUC decreased by 92%, Cmax by 89%, Cmin by 75%) and active metabolite M8 levels. The mechanism involves increased gastric ph reducing absorption and possible cyp2c19 interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Esomeprazole Class
- Proton Pump Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased gastric pH reducing absorption and possible CYP2C19 interaction
What To Tell Your Doctor or Pharmacist
If you are taking Nelfinavir and your doctor is considering prescribing Esomeprazole (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider