Does Rifampin Interact with Linezolid?
Rifampin and Linezolid have a moderate drug interaction according to U.S. FDA drug labeling data. Co-administration of rifampin with linezolid resulted in 21% decrease in linezolid Cmax and 32% decrease in linezolid AUC. Clinical significance is unknown. The mechanism involves induction of hepatic enzymes. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Rifampin Class
- Rifamycin Antibacterial
- Linezolid Class
- Oxazolidinone Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Rifampin and Linezolid occurs because induction of hepatic enzymes. Clinically, this means co-administration of rifampin with linezolid resulted in 21% decrease in linezolid cmax and 32% decrease in linezolid auc. clinical significance is unknown. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Rifampin and your doctor is considering prescribing Linezolid (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider