Does Riociguat Interact with Abacavir Lamivudine And Zidovudine?
Riociguat and Abacavir Lamivudine And Zidovudine have a moderate drug interaction according to U.S. FDA drug labeling data. Coadministration with abacavir/lamivudine may increase riociguat exposure and risk of adverse reactions; riociguat dose reduction may be needed. The mechanism involves increased riociguat exposure. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Riociguat Class
- Soluble Guanylate Cyclase Stimulator
- Abacavir Lamivudine And Zidovudine Class
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Riociguat and Abacavir Lamivudine And Zidovudine occurs because increased riociguat exposure. Clinically, this means coadministration with abacavir/lamivudine may increase riociguat exposure and risk of adverse reactions; riociguat dose reduction may be needed. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Riociguat and your doctor is considering prescribing Abacavir Lamivudine And Zidovudine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider