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Does Riociguat Interact with Aluminum Hydroxide?

Riociguat and Aluminum Hydroxide have a moderate drug interaction according to U.S. FDA drug labeling data. Separate administration by at least 1 hour. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Riociguat Class
Soluble Guanylate Cyclase Stimulator
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Riociguat and your doctor is considering prescribing Aluminum Hydroxide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Riociguat(Adempas)+💊 Aluminum Hydroxide(Milantex)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Soluble Guanylate Cyclase Stimulator
Drug B class
—
Source
NLP:riociguat

What this means in plain English

Separate administration by at least 1 hour.

About Riociguat and Aluminum Hydroxide

Riociguat is a Soluble Guanylate Cyclase Stimulator. You may recognize them by the brand names Adempas and Milantex. Riociguat is taken by mouth. Riociguat additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.