Risdiplam + Metformin Interaction
Moderateinteraction on record
Description
EVRYSDI may increase plasma concentrations of metformin, a MATE1/MATE2-K substrate. Avoid coadministration; if unavoidable, monitor for toxicities and consider dosage reduction.
Mechanism
Inhibition of MATE1 or MATE2-K transporters
Source: NLP:risdiplam