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Does Ritonavir Interact with Norethindrone And Ethinyl Estradiol?

Ritonavir and Norethindrone And Ethinyl Estradiol have a contraindicated drug interaction according to U.S. FDA drug labeling data. Do not co-administer with HCV combination therapy containing ombitasvir/paritaprevir/ritonavir due to potential for ALT elevations. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Ritonavir Class
Cytochrome P450 3A Inhibitor
Norethindrone And Ethinyl Estradiol Class
Estrogen
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Ritonavir and your doctor is considering prescribing Norethindrone And Ethinyl Estradiol (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Ritonavir(Norvir)+💊 Norethindrone And Ethinyl Estradiol(Wymzya Fe)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Cytochrome P450 3A Inhibitor
Drug B class
Estrogen
Source
NLP:norethindrone and ethinyl estradiol

What this means in plain English

Do not co-administer with HCV combination therapy containing ombitasvir/paritaprevir/ritonavir due to potential for ALT elevations.

About Ritonavir and Norethindrone And Ethinyl Estradiol

Ritonavir is a Cytochrome P450 3A Inhibitor, while Norethindrone And Ethinyl Estradiol is an Estrogen. You may recognize them by the brand names Norvir and Wymzya Fe. Both medications are taken by mouth. Both Ritonavir and Norethindrone And Ethinyl Estradiol carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.