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Does Rituximab Interact with Adalimumab Adaz?

Rituximab and Adalimumab Adaz have a major drug interaction according to U.S. FDA drug labeling data. A higher rate of serious infections has also been observed in patients with RA treated with rituximab who received subsequent treatment with a TNF-blocker. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Rituximab Class
CD20-directed Cytolytic Antibody
Adalimumab Adaz Class
Tumor Necrosis Factor Blocker
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Rituximab and your doctor is considering prescribing Adalimumab Adaz (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Rituximab(Rituxan Hycela)+💊 Adalimumab Adaz(Hyrimoz)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
CD20-directed Cytolytic Antibody
Drug B class
Tumor Necrosis Factor Blocker
Source
FDA drug label - adalimumab-adaz

What this means in plain English

A higher rate of serious infections has also been observed in patients with RA treated with rituximab who received subsequent treatment with a TNF-blocker.

About Rituximab and Adalimumab Adaz

Rituximab is a CD20-directed Cytolytic Antibody, while Adalimumab Adaz is a Tumor Necrosis Factor Blocker. You may recognize them by the brand names Rituxan Hycela and Hyrimoz. Rituximab is given by intravenous (IV) infusion, whereas Adalimumab Adaz is given by injection under the skin. Both Rituximab and Adalimumab Adaz carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.