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Does Sarilumab Interact with Lovastatin?

Sarilumab and Lovastatin have a moderate drug interaction according to U.S. FDA drug labeling data. Exercise caution when co-administering KEVZARA with CYP3A4 substrate drugs where decrease in effectiveness is undesirable, e.g., oral contraceptives, lovastatin, atorvastatin, etc. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Sarilumab Class
Interleukin-6 Receptor Antagonist
Lovastatin Class
HMG-CoA Reductase Inhibitor
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Sarilumab and your doctor is considering prescribing Lovastatin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Sarilumab(Kevzara)+💊 Lovastatin(Altoprev)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Interleukin-6 Receptor Antagonist
Drug B class
HMG-CoA Reductase Inhibitor
Source
FDA drug label - sarilumab

What this means in plain English

Exercise caution when co-administering KEVZARA with CYP3A4 substrate drugs where decrease in effectiveness is undesirable, e.g., oral contraceptives, lovastatin, atorvastatin, etc.

About Sarilumab and Lovastatin

Sarilumab is an Interleukin-6 Receptor Antagonist, while Lovastatin is a HMG-CoA Reductase Inhibitor. You may recognize them by the brand names Kevzara and Altoprev. Sarilumab is given by injection under the skin, whereas Lovastatin is taken by mouth. Sarilumab additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.