Does Selective Serotonin Reuptake Inhibitors Ssri Interact with Cyclobenzaprine Hydrochloride?
CDI records a major classification for Selective Serotonin Reuptake Inhibitors Ssri and Cyclobenzaprine Hydrochloride. The stored summary is: Postmarketing cases of serotonin syndrome reported during combined use. Careful observation advised, particularly during treatment initiation or dose increases. The mechanism involves serotonergic activity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Serotonergic activity
What To Tell Your Doctor or Pharmacist
If you are taking Selective Serotonin Reuptake Inhibitors Ssri and your doctor is considering prescribing Cyclobenzaprine Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider