Does Selective Serotonin Reuptake Inhibitors Ssri Interact with Granisetron?
CDI records a moderate classification for Selective Serotonin Reuptake Inhibitors Ssri and Granisetron. The stored summary is: Concomitant use may cause serotonin syndrome including altered mental status, autonomic instability, and neuromuscular symptoms. Monitor for emergence of serotonin syndrome. The mechanism involves additive serotonergic activity. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Granisetron Class
- Serotonin-3 Receptor Antagonist
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Additive serotonergic activity
What To Tell Your Doctor or Pharmacist
If you are taking Selective Serotonin Reuptake Inhibitors Ssri and your doctor is considering prescribing Granisetron (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider