Does Selective Serotonin Reuptake Inhibitors Ssri Interact with Palonosetron Hydrochloride?
CDI records a major classification for Selective Serotonin Reuptake Inhibitors Ssri and Palonosetron Hydrochloride. The stored summary is: Concomitant use may cause serotonin syndrome including altered mental status, autonomic instability, and neuromuscular symptoms. Monitor for emergence and discontinue palonosetron if symptoms occur. The mechanism involves additive serotonergic effects via 5-ht3 receptor antagonism and serotonin reuptake inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Additive serotonergic effects via 5-HT3 receptor antagonism and serotonin reuptake inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Selective Serotonin Reuptake Inhibitors Ssri and your doctor is considering prescribing Palonosetron Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider