Does Sensitive Cyp3a Substrates Interact with Viloxazine Hydrochloride?
Sensitive Cyp3a Substrates and Viloxazine Hydrochloride have a moderate drug interaction according to U.S. FDA drug labeling data. Viloxazine significantly increases total exposure of these substrates, which may increase adverse reaction risk. Not recommended for coadministration; dose reduction may be warranted if coadministered. The mechanism involves strong cyp1a2 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Sensitive Cyp3a Substrates and Viloxazine Hydrochloride occurs because strong cyp1a2 inhibition. Clinically, this means viloxazine significantly increases total exposure of these substrates, which may increase adverse reaction risk. not recommended for coadministration; dose reduction may be warranted if coadministered. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Sensitive Cyp3a Substrates and your doctor is considering prescribing Viloxazine Hydrochloride (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider