Does Sertraline Hydrochloride Interact with Selegiline?
CDI records a contraindicated classification for Sertraline Hydrochloride and Selegiline. The stored summary is: Concomitant use of MAOI selegiline with sertraline hydrochloride increases risk of serotonin syndrome. The mechanism involves maoi interaction increases serotonin levels. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Selegiline Class
- Monoamine Oxidase Inhibitor
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
MAOI interaction increases serotonin levels
What To Tell Your Doctor or Pharmacist
If you are taking Sertraline Hydrochloride and your doctor is considering prescribing Selegiline (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider