Selegiline has 30 known drug interactions based on U.S. FDA drug labeling data. Of these, 21 are contraindicated combinations that should be avoided entirely. 4 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Carbidopa, Carbidopa And Levodopa, Carbidopa Tablets. Patients taking Selegiline should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 30
- Contraindicated
- 21
- Major
- 4
- Moderate
- 3
Contraindicated (21)
- Selegiline + Carbidopa— Concomitant therapy may be associated with severe orthostatic hypotension not attributable to carbidopa-levodopa alone.
- Selegiline + Carbidopa And Levodopa— Concomitant therapy may be associated with severe orthostatic hypotension not attributable to carbidopa and levodopa alo…
- Selegiline + Carbidopa Tablets— Concomitant therapy may be associated with severe orthostatic hypotension; contraindicated per label.
- Selegiline + Desvenlafaxine— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping MAOI.
- Selegiline + Desvenlafaxine Er— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOIs intended to treat psychiatric disorders…
- Selegiline + Desvenlafaxine Succinate— Concomitant use increases risk of serotonin syndrome. Contraindicated with MAOI intended to treat psychiatric disorders …
- Selegiline + Dexmethylphenidate Hydrochloride— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Selegiline + Dextroamphetamine Saccharate, Amphetamine Aspartate Monohydrate, Dextroamphetamine Sulfate And Amphetamine Sulfate— MAOI that potentiates amphetamine effects; concomitant use can cause hypertensive crisis with potentially fatal outcomes…
- Selegiline + Dextroamphetamine Sulfate— MAOI concomitant use can cause hypertensive crisis with potentially fatal outcomes including stroke, myocardial infarcti…
- Selegiline + Duloxetine— Concomitant use increases risk of serotonin syndrome. Use of selegiline with duloxetine or within 5 days of stopping dul…
- Selegiline + Levomilnacipran Hydrochloride— MAOI that increases risk of serotonin syndrome when used with levomilnacipran. Contraindicated use.
- Selegiline + Methylphenidate Hydrochloride— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, an…
- Selegiline + Methylphenidate Hydrochloride Extended Release— Concomitant use can cause hypertensive crisis with potential outcomes including death, stroke, myocardial infarction, ao…
- Selegiline + Mirtazapine— Concomitant use increases risk of serotonin syndrome. Mirtazapine is contraindicated in patients taking MAOIs.
- Selegiline + Paroxetine— MAOI that increases risk of serotonin syndrome when combined with paroxetine. Paroxetine is contraindicated.
- Selegiline + Paroxetine Hydrochloride— Concomitant use of SSRIs including paroxetine and MAOIs increases the risk of serotonin syndrome.
- Selegiline + Paroxetine Hydrochloride Hemihydrate— Concomitant use increases risk of serotonin syndrome.
- Selegiline + Sertraline— Concomitant use increases risk of serotonin syndrome. Sertraline is contraindicated in patients taking MAOIs.
- Selegiline + Sertraline Hydrochloride— Concomitant use of MAOI selegiline with sertraline hydrochloride increases risk of serotonin syndrome.
- Selegiline + Trazodone Hydrochloride— Concomitant use increases risk of serotonin syndrome. Trazodone is contraindicated in patients taking MAOIs.
- Selegiline + Vortioxetine— Concomitant use with MAOIs increases risk of serotonin syndrome. Contraindicated with MAOI or within 14 days of stopping…
Major (4)
- Selegiline + Dopamine Hydrochloride— Inhibition of MAO prolongs and potentiates dopamine effects, potentially resulting in severe hypertension and cardiac ar…
- Selegiline + Phenylephrine Hci— Monoamine oxidase inhibitor that increases the pressor effect of phenylephrine hydrochloride.
- Selegiline + Phenylephrine Hydrochloride— Monoamine oxidase inhibitor that increases the pressor effect of phenylephrine hydrochloride.
- Selegiline + Phenylephrine Hydrochloride Injection, Solution— Monoamine oxidase inhibitor increases pressor effect of phenylephrine hydrochloride, potentially causing dangerous hyper…
Moderate (3)
- Selegiline + Droxidopa— Selective MAO-B inhibitor permitted in clinical trials but use with caution; monitor for increased blood pressure.
- Selegiline + Foscarbidopa/Foslevodopa— Selective MAO-B inhibitor may cause orthostatic hypotension with VYALEV. Monitor patients taking these drugs.
- Selegiline + Ioflupane I-123— Binds to dopamine transporter with high affinity and may interfere with Ioflupane I-123 imaging results.