Does Sildenafil Interact with Hydralazine Hydrochloride And Isosorbide Dinitrate?
CDI records a contraindicated classification for Sildenafil and Hydralazine Hydrochloride And Isosorbide Dinitrate. The stored summary is: PDE5 inhibitor potentiates hypotensive effects of isosorbide dinitrate. Contraindicated. The mechanism involves potentiation of hypotensive effects via pde5 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Sildenafil Class
- Phosphodiesterase 5 Inhibitor
- Hydralazine Hydrochloride And Isosorbide Dinitrate Class
- Nitrate Vasodilator
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Potentiation of hypotensive effects via PDE5 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Sildenafil and your doctor is considering prescribing Hydralazine Hydrochloride And Isosorbide Dinitrate (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider