Does Sildenafil Interact with Riociguat?
CDI records a contraindicated classification for Sildenafil and Riociguat. The stored summary is: Co-administration with sildenafil is contraindicated because of hypotension. Do not administer within 24 hours of sildenafil. The mechanism involves pde-5 inhibitor interaction causing hypotension. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Contraindicated
- Sildenafil Class
- Phosphodiesterase 5 Inhibitor
- Riociguat Class
- Soluble Guanylate Cyclase Stimulator
- Management
- Do not take together
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
PDE-5 inhibitor interaction causing hypotension
What To Tell Your Doctor or Pharmacist
If you are taking Sildenafil and your doctor is considering prescribing Riociguat (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask about alternative medications that do not interact with your current regimen
- Ask how frequently you should be monitored while these are co-prescribed
- Never stop or change either medication without first consulting your healthcare provider