Does Siltuximab Interact with Cyclosporine?
Siltuximab and Cyclosporine have a moderate drug interaction according to U.S. FDA drug labeling data. SILTUXIMAB may restore CYP450 activities leading to increased metabolism of cyclosporine. Drug concentration monitoring and dose adjustment recommended upon initiation or discontinuation. The mechanism involves inhibition of il-6 signaling restores cyp450 enzyme activity, increasing drug metabolism. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Siltuximab Class
- Interleukin-6 Antagonist
- Cyclosporine Class
- Calcineurin Inhibitor Immunosuppressant
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Siltuximab and Cyclosporine occurs because inhibition of il-6 signaling restores cyp450 enzyme activity, increasing drug metabolism. Clinically, this means siltuximab may restore cyp450 activities leading to increased metabolism of cyclosporine. drug concentration monitoring and dose adjustment recommended upon initiation or discontinuation. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Siltuximab and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider