Does Simvastatin Interact with Tocilizumab?
CDI records a moderate classification for Simvastatin and Tocilizumab. The stored summary is: Tocilizumab may decrease simvastatin exposure by up to 57% due to increased CYP3A4 metabolism. Dose adjustment may be needed. The mechanism involves inhibition of il-6 signaling restores cyp450 activities, increasing metabolism of cyp3a4 substrates. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
Evidence status
A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.
Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.
- Stored CDI classification
- Moderate
- Simvastatin Class
- HMG-CoA Reductase Inhibitor
- Tocilizumab Class
- Interleukin-6 Receptor Antagonist
- Management
- Confirm exact products with your pharmacist
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of IL-6 signaling restores CYP450 activities, increasing metabolism of CYP3A4 substrates
What To Tell Your Doctor or Pharmacist
If you are taking Simvastatin and your doctor is considering prescribing Tocilizumab (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider