Does Infliximab Axxq Interact with Tocilizumab?
CDI records a major classification for Infliximab Axxq and Tocilizumab. The stored summary is: Concomitant use should be avoided due to possibility of increased immunosuppression and increased risk of infection when combined with TNF antagonists. The mechanism involves increased immunosuppression and infection risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Infliximab Axxq Class
- Tumor Necrosis Factor Blocker
- Tocilizumab Class
- Interleukin-6 Receptor Antagonist
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Increased immunosuppression and infection risk
What To Tell Your Doctor or Pharmacist
If you are taking Infliximab Axxq and your doctor is considering prescribing Tocilizumab (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider