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Does Simvastatin Interact with Voclosporin?

Simvastatin and Voclosporin have a major drug interaction according to U.S. FDA drug labeling data. OATP1B1 substrate; voclosporin increases simvastatin acid exposure 3.1-fold (Cmax) and 1.8-fold (AUC). Monitor for myopathy and rhabdomyolysis; limit simvastatin to 20 mg daily. The mechanism involves oatp1b1 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Simvastatin Class
HMG-CoA Reductase Inhibitor
Voclosporin Class
Calcineurin Inhibitor Immunosuppressant
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Simvastatin and Voclosporin occurs because oatp1b1 inhibition. Clinically, this means oatp1b1 substrate; voclosporin increases simvastatin acid exposure 3.1-fold (cmax) and 1.8-fold (auc). monitor for myopathy and rhabdomyolysis; limit simvastatin to 20 mg daily. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Simvastatin and your doctor is considering prescribing Voclosporin (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Simvastatin+💊 Voclosporin(Lupkynis)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
HMG-CoA Reductase Inhibitor
Drug B class
Calcineurin Inhibitor Immunosuppressant
Source
NLP:voclosporin

What this means in plain English

OATP1B1 substrate; voclosporin increases simvastatin acid exposure 3.1-fold (Cmax) and 1.8-fold (AUC). Monitor for myopathy and rhabdomyolysis; limit simvastatin to 20 mg daily.

What the FDA label says

"OATP1B1 inhibition"

📖 Source: NLP:voclosporin

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.