Does Sitagliptin Hydrochloride Oral Interact with Sulfonylurea?
CDI records a moderate classification for Sitagliptin Hydrochloride Oral and Sulfonylurea. The stored summary is: Coadministration may require lower dosages of sulfonylurea to reduce the risk of hypoglycemia. The mechanism involves sitagliptin lowers blood glucose; additive effect increases hypoglycemia risk. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Sitagliptin Hydrochloride Oral Class
- Dipeptidyl Peptidase 4 Inhibitor
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Sitagliptin lowers blood glucose; additive effect increases hypoglycemia risk
What To Tell Your Doctor or Pharmacist
If you are taking Sitagliptin Hydrochloride Oral and your doctor is considering prescribing Sulfonylurea (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider