Does Sodium Zirconium Cyclosilicate Interact with Furosemide?
CDI records a moderate classification for Sodium Zirconium Cyclosilicate and Furosemide. The stored summary is: LOKELMA increases systemic exposure to furosemide by elevating gastric pH. Separate administration by at least 2 hours. The mechanism involves ph-dependent solubility; lokelma elevates gastric ph. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Furosemide Class
- Loop Diuretic
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
pH-dependent solubility; LOKELMA elevates gastric pH
What To Tell Your Doctor or Pharmacist
If you are taking Sodium Zirconium Cyclosilicate and your doctor is considering prescribing Furosemide (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider