Does Sotagliflozin Interact with Rifampin?
CDI records a moderate classification for Sotagliflozin and Rifampin. The stored summary is: Rifampin induces UGT1A9, decreasing sotagliflozin exposure and potentially reducing efficacy. Consider monitoring of clinical status. The mechanism involves ugt1a9 induction reduces sotagliflozin glucuronidation. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Sotagliflozin Class
- Sodium-Glucose Cotransporter 2 Inhibitor
- Rifampin Class
- Rifamycin Antibacterial
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
UGT1A9 induction reduces sotagliflozin glucuronidation
What To Tell Your Doctor or Pharmacist
If you are taking Sotagliflozin and your doctor is considering prescribing Rifampin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider