Home›Spironolactone›Spironolactone + Abiraterone

Does Spironolactone Interact with Abiraterone?

Spironolactone and Abiraterone have a contraindicated drug interaction according to U.S. FDA drug labeling data. Spironolactone binds to androgen receptor and may increase PSA levels in abiraterone-treated prostate cancer patients. Concomitant use not recommended. The mechanism involves androgen receptor binding interference. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Spironolactone Class
Aldosterone Antagonist
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Spironolactone and Abiraterone occurs because androgen receptor binding interference. Clinically, this means spironolactone binds to androgen receptor and may increase psa levels in abiraterone-treated prostate cancer patients. concomitant use not recommended. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Spironolactone and your doctor is considering prescribing Abiraterone (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Spironolactone(Spironolactone)+💊 Abiraterone(Abiraterone Acetate)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Aldosterone Antagonist
Drug B class
—
Source
NLP:spironolactone

What this means in plain English

Spironolactone binds to androgen receptor and may increase PSA levels in abiraterone-treated prostate cancer patients. Concomitant use not recommended.

What the FDA label says

"Androgen receptor binding interference"

📖 Source: NLP:spironolactone

Share this result:XFacebookWhatsAppReddit
Add more drugs
Check Spironolactone and Abiraterone against your full medication list

Most patients take more than two medications. CDI checks every pair across up to 20 drugs simultaneously — including OTCs and common supplements.

Add more drugs →

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.