Statins + Diltiazem Hydrochloride Interaction

Majorinteraction on record

Description

Increased risk of myopathy and rhabdomyolysis with statins metabolized by CYP3A4. Limit simvastatin to 10 mg daily and diltiazem to 240 mg.

Mechanism

Diltiazem inhibits CYP3A4 metabolism of statins

Source: NLP:diltiazem hydrochloride