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Does Strong Inhibitors Of Cyp2d6 Interact with Triazolam?

Strong Inhibitors Of Cyp2d6 and Triazolam have a contraindicated drug interaction according to U.S. FDA drug labeling data. Concomitant use has profound effect on triazolam clearance, resulting in increased concentrations and increased risk of adverse reactions. Do not administer triazolam with strong CYP3A4 inhibitors. The mechanism involves decreased clearance of triazolam via cyp3a4 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Triazolam Class
Benzodiazepine
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Strong Inhibitors Of Cyp2d6 and Triazolam occurs because decreased clearance of triazolam via cyp3a4 inhibition. Clinically, this means concomitant use has profound effect on triazolam clearance, resulting in increased concentrations and increased risk of adverse reactions. do not administer triazolam with strong cyp3a4 inhibitors. Because of the severity of this interaction, these medications are contraindicated — meaning they should not be taken together under any circumstances. If you are currently taking both, contact your healthcare provider immediately to discuss alternatives.

What To Tell Your Doctor or Pharmacist

If you are taking Strong Inhibitors Of Cyp2d6 and your doctor is considering prescribing Triazolam (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Strong Inhibitors Of Cyp2d6+💊 Triazolam

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Benzodiazepine
Source
NLP:triazolam

What this means in plain English

Concomitant use has profound effect on triazolam clearance, resulting in increased concentrations and increased risk of adverse reactions. Do not administer triazolam with strong CYP3A4 inhibitors.

What the FDA label says

"Decreased clearance of triazolam via CYP3A4 inhibition"

📖 Source: NLP:triazolam

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.