Does Sucralfate Interact with Phenytoin?
CDI records a moderate classification for Sucralfate and Phenytoin. The stored summary is: Sucralfate reduces the bioavailability of phenytoin. Separate dosing administration is recommended. The mechanism involves sucralfate binding to phenytoin in the gastrointestinal tract. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Sucralfate Class
- Aluminum Complex
- Phenytoin Class
- Anti-epileptic Agent
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Sucralfate binding to phenytoin in the gastrointestinal tract
What To Tell Your Doctor or Pharmacist
If you are taking Sucralfate and your doctor is considering prescribing Phenytoin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider