Sucralfate has 24 known drug interactions based on U.S. FDA drug labeling data. 1 are classified as major interactions requiring close medical supervision. Notable interactions include combinations with Ciprofloxacin, Cimetidine, Delafloxacin Meglumine. Patients taking Sucralfate should inform their healthcare provider of all current medications — including over-the-counter drugs and supplements — to avoid potentially harmful combinations. Data sourced from OpenFDA and the NIH National Library of Medicine.
- Total
- 24
- Major
- 1
- Moderate
- 23
Major (1)
- Sucralfate + Ciprofloxacin— Concurrent administration may substantially decrease ciprofloxacin absorption, resulting in serum and urine levels consi…
Moderate (23)
- Sucralfate + Cimetidine— Sucralfate reduces the bioavailability of cimetidine. Dosing cimetidine 2 hours before sucralfate eliminates the interac…
- Sucralfate + Delafloxacin Meglumine— Sucralfate forms chelates with delafloxacin, substantially interfering with absorption and resulting in considerably low…
- Sucralfate + Digoxin— Sucralfate reduces the bioavailability of digoxin. Dosing digoxin 2 hours before sucralfate eliminates the interaction.
- Sucralfate + Furosemide— Simultaneous administration of sucralfate and furosemide may reduce natriuretic and antihypertensive effects. Separate i…
- Sucralfate + Furosemide, Benzalkonium Chloride— Simultaneous administration of sucralfate and furosemide tablets may reduce the natriuretic and antihypertensive effects…
- Sucralfate + Ketoconazole— Sucralfate reduces the bioavailability of ketoconazole. Monitor absorption when used concomitantly.
- Sucralfate + L-Thyroxine— Sucralfate reduces the bioavailability of l-thyroxine. Separate dosing administration is recommended.
- Sucralfate + Levofloxacin— Absorption of levofloxacin is decreased when tablets are taken within 2 hours, resulting in considerably lower systemic …
- Sucralfate + Levothyroxine Sodium— May cause hypochlorhydria and affect intragastric pH, reducing levothyroxine absorption. Monitor patients appropriately.
- Sucralfate + Macrolide Antibiotics— Sucralfate reduces the bioavailability of fluoroquinolone antibiotics. Dosing 2 hours before sucralfate eliminates the i…
- Sucralfate + Moxifloxacin— Forms chelates with moxifloxacin, substantially decreasing absorption. Take moxifloxacin at least 4 hours before or 8 ho…
- Sucralfate + Moxifloxacin Hydrochloride— Decreased moxifloxacin absorption due to chelate formation. Take moxifloxacin at least 4 hours before or 8 hours after s…
- Sucralfate + Moxifloxacin Hydrochloride Tablets, 400 Mg— Sucralfate forms chelates with moxifloxacin, substantially interfering with absorption. Take moxifloxacin at least 4 hou…
- Sucralfate + Naproxen— Concomitant administration can delay the absorption of naproxen.
- Sucralfate + Norfloxacin— Sucralfate reduces the bioavailability of norfloxacin. Dosing norfloxacin 2 hours before sucralfate eliminates the inter…
- Sucralfate + Ofloxacin— Sucralfate reduces the bioavailability of ofloxacin. Dosing ofloxacin 2 hours before sucralfate eliminates the interacti…
- Sucralfate + Phenytoin— Sucralfate reduces the bioavailability of phenytoin. Separate dosing administration is recommended.
- Sucralfate + Phenytoin Sodium— May decrease phenytoin serum levels; monitoring of phenytoin levels recommended.
- Sucralfate + Quinidine— Sucralfate reduces the bioavailability of quinidine. Separate dosing administration is recommended.
- Sucralfate + Ranitidine— Sucralfate reduces the bioavailability of ranitidine. Dosing ranitidine 2 hours before sucralfate eliminates the interac…
- Sucralfate + Tetracycline— Sucralfate reduces the bioavailability of tetracycline. Separate dosing administration is recommended.
- Sucralfate + Theophylline— Sucralfate reduces the bioavailability of theophylline. Separate dosing administration is recommended.
- Sucralfate + Warfarin— Subtherapeutic prothrombin times reported with concomitant warfarin and sucralfate; however, clinical studies showed no …