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Does Sulfamethoxazole Interact with Dapsone Gel 5?

CDI records a unknown classification for Sulfamethoxazole and Dapsone Gel 5. The stored summary is: 7 DRUG INTERACTIONS Trimethoprim/sulfamethoxazole (TMP/ SMX) increases the level of dapsone and its metabolites ( 7.1 ) Topical benzoyl peroxide used at the same time as dapsone may result in temporary local yellow or orange skin discoloration. 7.1 Trimethoprim – Sulfamethoxazole A drug-drug interaction study evaluated the effect of the use of Dapsone Gel, 5%, in combination with double strength (160 mg/800 mg) trimethoprim-sulfamethoxazole (TMP/SMX). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.

Evidence status

A current label comparison is not yet available for this record. The summary and severity are stored CDI information; they have not been independently validated on this page against the exact product label.

Confirm the medicine, formulation, route, and applicable warning with your pharmacist or prescriber. Independent clinical review has not been recorded.

Stored CDI classification
Unknown
Dapsone Gel 5 Class
Sulfone
Management
Confirm exact products with your pharmacist
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Sulfamethoxazole and your doctor is considering prescribing Dapsone Gel 5 (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Sulfamethoxazole(Bactrim)+💊 Dapsone Gel 5(Dapsone)

Severity & Interaction Details

ℹ️
unknown
Stored CDI classification: unknown
A current source comparison has not been recorded for this claim. The stored classification does not determine the clinical significance for your exact products or circumstances.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Sulfone
Source
FDA drug label - dapsone gel, 5%

What this means in plain English

7 DRUG INTERACTIONS Trimethoprim/sulfamethoxazole (TMP/ SMX) increases the level of dapsone and its metabolites ( 7.1 ) Topical benzoyl peroxide used at the same time as dapsone may result in temporary local yellow or orange skin discoloration. 7.1 Trimethoprim – Sulfamethoxazole A drug-drug interaction study evaluated the effect of the use of Dapsone Gel, 5%, in combination with double strength (160 mg/800 mg) trimethoprim-sulfamethoxazole (TMP/SMX).

About Sulfamethoxazole and Dapsone Gel 5

Dapsone Gel 5 is a Sulfone. Sulfamethoxazole is also sold under the brand name Bactrim.

Source and Limitations

This record was produced by automated extraction from drug-label information, including AI processing. The summary and mechanism are not verbatim FDA quotations. The drug profiles below may describe different formulations from the source label. Confirm the exact product and route with your pharmacist. This page does not establish independent clinical review.

📖 Source: FDA drug label - dapsone gel, 5%

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How this information is prepared: CDI uses automated extraction, including AI, to summarize drug labeling from openFDA and includes separately identified curated-reference records. RxNorm helps identify medications; it does not verify interaction claims. Extracted summaries and CDI severity classifications can contain errors and are not verbatim FDA statements or independent clinical review. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.

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