Does Sulfamethoxazole Interact with Dapsone Gel 5?
Sulfamethoxazole and Dapsone Gel 5 have a unknown drug interaction according to U.S. FDA drug labeling data. 7 DRUG INTERACTIONS Trimethoprim/sulfamethoxazole (TMP/ SMX) increases the level of dapsone and its metabolites ( 7.1 ) Topical benzoyl peroxide used at the same time as dapsone may result in temporary local yellow or orange skin discoloration. 7.1 Trimethoprim – Sulfamethoxazole A drug-drug interaction study evaluated the effect of the use of Dapsone Gel, 5%, in combination with double strength (160 mg/800 mg) trimethoprim-sulfamethoxazole (TMP/SMX). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Unknown
- Dapsone Gel 5 Class
- Sulfone
- Management
- Consult your pharmacist
- Data Source
- U.S. FDA via OpenFDA
What To Tell Your Doctor or Pharmacist
If you are taking Sulfamethoxazole and your doctor is considering prescribing Dapsone Gel 5 (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Never stop or change either medication without first consulting your healthcare provider