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Does Sulfamethoxazole And Trimethoprim Interact with Cyclosporine?

Sulfamethoxazole And Trimethoprim and Cyclosporine have a contraindicated drug interaction according to U.S. FDA drug labeling data. Marked but reversible nephrotoxicity reported with coadministration in renal transplant recipients. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Contraindicated
Sulfamethoxazole And Trimethoprim Class
Sulfonamide Antimicrobial
Cyclosporine Class
Calcineurin Inhibitor Immunosuppressant
Management
Do not take together
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Sulfamethoxazole And Trimethoprim and your doctor is considering prescribing Cyclosporine (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask about alternative medications that do not interact with your current regimen
  • Ask how frequently you should be monitored while these are co-prescribed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Sulfamethoxazole And Trimethoprim(Bactrim)+💊 Cyclosporine(Neoral)

Severity & Interaction Details

⛔
contraindicated
Avoid this combination
FDA labeling lists this pair as contraindicated. The risk outweighs the benefit in nearly all cases.
Severity scale
MinorContra
On record
Yes
Drug A class
Sulfonamide Antimicrobial
Drug B class
Calcineurin Inhibitor Immunosuppressant
Source
NLP:sulfamethoxazole and trimethoprim

What this means in plain English

Marked but reversible nephrotoxicity reported with coadministration in renal transplant recipients.

About Sulfamethoxazole And Trimethoprim and Cyclosporine

Sulfamethoxazole And Trimethoprim is a Sulfonamide Antimicrobial, while Cyclosporine is a Calcineurin Inhibitor Immunosuppressant. You may recognize them by the brand names Bactrim and Neoral. Both medications are taken by mouth. Cyclosporine additionally carries an FDA boxed warning, the FDA's strongest safety alert.

Recent research & FDA safety updates

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.