Does Sulfamethoxazole And Trimethoprim Interact with Warfarin?
CDI records a major classification for Sulfamethoxazole And Trimethoprim and Warfarin. The stored summary is: BACTRIM may prolong prothrombin time in patients receiving warfarin. Sulfamethoxazole inhibits CYP2C9, increasing warfarin levels. The mechanism involves cyp2c9 inhibition. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Major
- Sulfamethoxazole And Trimethoprim Class
- Sulfonamide Antimicrobial
- Management
- Close medical supervision required
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
CYP2C9 inhibition
What To Tell Your Doctor or Pharmacist
If you are taking Sulfamethoxazole And Trimethoprim and your doctor is considering prescribing Warfarin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask how frequently you should be monitored while these are co-prescribed
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider