Does Sulindac Interact with Probenecid And Colchicine?
Sulindac and Probenecid And Colchicine have a moderate drug interaction according to U.S. FDA drug labeling data. Probenecid increases plasma levels of sulindac and sulfone metabolite, and sulindac modestly reduces probenecid's uricosuric action. The mechanism involves decreased renal excretion; mutual interaction. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Sulindac Class
- Nonsteroidal Anti-inflammatory Drug
- Probenecid And Colchicine Class
- Alkaloid
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Sulindac and Probenecid And Colchicine occurs because decreased renal excretion; mutual interaction. Clinically, this means probenecid increases plasma levels of sulindac and sulfone metabolite, and sulindac modestly reduces probenecid's uricosuric action. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Sulindac and your doctor is considering prescribing Probenecid And Colchicine (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider