Does Sulopenem Etzadroxil And Probenecid Interact with Indomethacin?
CDI records a moderate classification for Sulopenem Etzadroxil And Probenecid and Indomethacin. The stored summary is: Probenecid inhibits OAT1/3, increasing indomethacin plasma concentrations and risk of adverse reactions. May require dosage adjustment. The mechanism involves inhibition of organic anion transporters 1 and 3 (oat1/3). Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This record was extracted from drug labeling through openFDA. NIH/NLM RxNorm is used for drug identities. The summary and severity classification are CDI's processed information, not a verbatim source quotation. Product, route, and patient circumstances matter.
- Severity
- Moderate
- Indomethacin Class
- Nonsteroidal Anti-inflammatory Drug
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
Recorded Mechanism
Inhibition of organic anion transporters 1 and 3 (OAT1/3)
What To Tell Your Doctor or Pharmacist
If you are taking Sulopenem Etzadroxil And Probenecid and your doctor is considering prescribing Indomethacin (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider