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Does Tecovirimat Monohydrate Interact with Midazolam?

Tecovirimat Monohydrate and Midazolam have a moderate drug interaction according to U.S. FDA drug labeling data. CNS Depressant: Midazolam b ↓ midazolam Monitor for effectiveness of midazolam. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Moderate
Tecovirimat Monohydrate Class
Orthopoxvirus VP37 Envelope Wrapping Protein Inhibitor
Midazolam Class
Benzodiazepine
Management
Monitor for effects
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Tecovirimat Monohydrate and your doctor is considering prescribing Midazolam (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tecovirimat Monohydrate(Tpoxx)+💊 Midazolam(Nayzilam)

Severity & Interaction Details

🟡
moderate
Be aware — moderate interaction
Documented interaction with manageable risk. May require dose adjustment or monitoring.
Severity scale
MinorContra
On record
Yes
Drug A class
Orthopoxvirus VP37 Envelope Wrapping Protein Inhibitor
Drug B class
Benzodiazepine
Source
FDA drug label - tecovirimat monohydrate

What this means in plain English

CNS Depressant: Midazolam b ↓ midazolam Monitor for effectiveness of midazolam.

About Tecovirimat Monohydrate and Midazolam

Tecovirimat Monohydrate is an Orthopoxvirus VP37 Envelope Wrapping Protein Inhibitor, while Midazolam is a Benzodiazepine. You may recognize them by the brand names Tpoxx and Nayzilam. Both medications are given by intravenous (IV) infusion. Midazolam additionally carries an FDA boxed warning, the FDA's strongest safety alert.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.