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Does Telotristat Ethyl Interact with Octreotide?

Telotristat Ethyl and Octreotide have a major drug interaction according to U.S. FDA drug labeling data. Concurrent administration of short-acting octreotide significantly decreases systemic exposure of telotristat ethyl and its active metabolite. Administer short-acting octreotide at least 30 minutes after telotristat ethyl. The mechanism involves decreased absorption of telotristat ethyl. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Major
Octreotide Class
Somatostatin Analog
Management
Close medical supervision required
Data Source
U.S. FDA via OpenFDA

How This Interaction Works

The interaction between Telotristat Ethyl and Octreotide occurs because decreased absorption of telotristat ethyl. Clinically, this means concurrent administration of short-acting octreotide significantly decreases systemic exposure of telotristat ethyl and its active metabolite. administer short-acting octreotide at least 30 minutes after telotristat ethyl. This is classified as a major interaction, meaning it could cause serious harm if not properly managed. Your healthcare provider may need to adjust dosages, substitute one medication, or increase monitoring frequency.

What To Tell Your Doctor or Pharmacist

If you are taking Telotristat Ethyl and your doctor is considering prescribing Octreotide (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Ask how frequently you should be monitored while these are co-prescribed
  • Ask whether any dosage adjustments are needed
  • Never stop or change either medication without first consulting your healthcare provider
💊 Telotristat Ethyl(Xermelo)+💊 Octreotide(Mycapssa)

Severity & Interaction Details

⚠️
major
Use with caution — major interaction
Serious risk of clinically significant harm. Generally avoid; if used, monitor closely.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Somatostatin Analog
Source
NLP:telotristat ethyl

What this means in plain English

Concurrent administration of short-acting octreotide significantly decreases systemic exposure of telotristat ethyl and its active metabolite. Administer short-acting octreotide at least 30 minutes after telotristat ethyl.

What the FDA label says

"Decreased absorption of telotristat ethyl"

📖 Source: NLP:telotristat ethyl

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Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine. For informational purposes only. Always consult your pharmacist or physician.