Does Tenapanor Hydrochloride Interact with Enalapril?
Tenapanor Hydrochloride and Enalapril have a moderate drug interaction according to U.S. FDA drug labeling data. Tenapanor inhibits OATP2B1 transporter, reducing enalapril peak exposure by ~70% and systemic exposure by 50-65%. Monitor blood pressure and adjust enalapril dosage as needed. The mechanism involves inhibition of intestinal oatp2b1 transporter-mediated uptake. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.
- Severity
- Moderate
- Management
- Monitor for effects
- Data Source
- U.S. FDA via OpenFDA
How This Interaction Works
The interaction between Tenapanor Hydrochloride and Enalapril occurs because inhibition of intestinal oatp2b1 transporter-mediated uptake. Clinically, this means tenapanor inhibits oatp2b1 transporter, reducing enalapril peak exposure by ~70% and systemic exposure by 50-65%. monitor blood pressure and adjust enalapril dosage as needed. This is classified as a moderate interaction. While it may not require stopping either medication, your healthcare provider should be aware you are taking both so they can monitor for potential effects and adjust treatment if necessary.
What To Tell Your Doctor or Pharmacist
If you are taking Tenapanor Hydrochloride and your doctor is considering prescribing Enalapril (or vice versa), make sure to:
- Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
- Ask whether the benefits of combining these medications outweigh the risks for your specific situation
- Ask what symptoms to watch for that would indicate the interaction is causing problems
- Ask whether any dosage adjustments are needed
- Never stop or change either medication without first consulting your healthcare provider