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Does Tenofovir Disoproxil Fumarate Interact with Entecavir?

Tenofovir Disoproxil Fumarate and Entecavir have a minor drug interaction according to U.S. FDA drug labeling data. Coadministration did not result in significant drug interactions. Patients taking both medications should consult their healthcare provider before starting, stopping, or changing the dosage of either drug. This information is based on official FDA drug labeling sourced from OpenFDA and the NIH National Library of Medicine.

Severity
Minor
Entecavir Class
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
Management
Generally manageable
Data Source
U.S. FDA via OpenFDA

What To Tell Your Doctor or Pharmacist

If you are taking Tenofovir Disoproxil Fumarate and your doctor is considering prescribing Entecavir (or vice versa), make sure to:

  • Inform your doctor and pharmacist of all current medications, including over-the-counter drugs and supplements
  • Ask whether the benefits of combining these medications outweigh the risks for your specific situation
  • Ask what symptoms to watch for that would indicate the interaction is causing problems
  • Never stop or change either medication without first consulting your healthcare provider
💊 Tenofovir Disoproxil Fumarate(Complera)+💊 Entecavir(Baraclude)

Severity & Interaction Details

✅
minor
Generally safe — minor interaction
Low clinical significance. Routine awareness is usually sufficient.
Severity scale
MinorContra
On record
Yes
Drug A class
—
Drug B class
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
Source
NLP:entecavir

What this means in plain English

Coadministration did not result in significant drug interactions.

About Tenofovir Disoproxil Fumarate and Entecavir

Entecavir is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. You may recognize them by the brand names Complera and Baraclude. Both medications are taken by mouth. Both Tenofovir Disoproxil Fumarate and Entecavir carry an FDA boxed warning — the agency's most serious safety designation.

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Data integrity: Every interaction shown is extracted directly from official U.S. FDA drug labeling via openFDA and the U.S. National Library of Medicine (NIH) — no interactions are invented, inferred, or manually edited. Maintained by CheckDrugInteractions.com. See our methodology or report a correction at support@checkdruginteractions.com.

Data sourced from U.S. FDA drug labeling via openFDA and the NIH National Library of Medicine, supplemented with a small number of well-established interactions from curated clinical references. For informational purposes only. Always consult your pharmacist or physician.